Dr. John's Health Matters
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The articles posted here are from various sources who are duly acknowledged. I would appreciate being immediately notified, if any copywritten material needs to be removed. This blog is not intended to replace the qualified advice of a licensed health practitioner. Readers should exercise their own judgment. Enjoy, subscribe, participate and tell others :)
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Posts tagged "vessel"
Wednesday, Sep 2nd, 2009 ↓Diesel Exhaust Is Linked To Cancer Development Via New Blood Vessel Growth →
Sept 2, 2009 (Sciencedaily.com)—Scientists have demonstrated that the link between diesel fume exposure and cancer lies in the ability of diesel exhaust to induce the growth of new blood vessels that serve as a food supply for solid tumors.
The researchers found that in both healthy and diseased animals, more new blood vessels sprouted in mice exposed to diesel exhaust than did in mice exposed to clean, filtered air. This suggests that previous illness isn’t required to make humans susceptible to the damaging effects of the diesel exhaust.
The tiny size of inhaled diesel particles, most less than 0.1 microns in diameter, potentially enables them to penetrate the human circulatory system, organs and tissues, meaning they can do this damage just about anywhere in the body. A micron is one millionth of a meter.
Diesel exhaust exposure levels in the study were designed to mimic the exposure people might experience while living in urban areas and commuting in heavy traffic. The levels were lower than or similar to those typically experienced by workers who use diesel-powered equipment, who tend to work in mines, on bridges and tunnels, along railroads, at loading docks, on farms and in vehicle maintenance garages, according to the U.S. Department of Labor.
“The message from our study is that exposure to diesel exhaust for just a short time period of two months could give even normal tissue the potential to develop a tumor,” said Qinghua Sun, senior author of the study and an assistant professor of environmental health sciences at Ohio State University.
“We need to raise public awareness so people give more thought to how they drive and how they live so they can pursue ways to protect themselves and improve their health. And we still have a lot of work to do to improve diesel engines so they generate fewer particles and exhaust that can be released into the ambient air.”
For full article, see link above.
Tags: disesel exhaust air damage risk cancer blood vessel tumor organ tissues circulatory system traffic environmental pollution
Surprising Rate Of Recurring Heart Attacks, Strokes Globally →
Aug 31, 2009 (Sciencedaily.com)—Despite many medicines and other treatments for patients with vascular disease, a large international study shows these patients have a surprisingly high rate of recurring events such as strokes, heart attacks and hospitalizations as well as mortality.
Also unexpected: patients in North America (including the U.S.) experienced an above-average rate of these events. Patients in Eastern Europe had the highest rate, and those in Australia and Japan had the lowest.
The results from the international REACH (Reduction of Atherothrombosis for Continued Health) Registry, presented by a researcher from Northwestern University Feinberg School of Medicine, examined data for 32,247 patients one and three years after they enrolled in the registry. Patients who had symptomatic vascular disease had a 14.4 percent rate at one year and 28.4 percent rate at three years of having a heart attack, stroke, rehospitalization for another type of vascular event or vascular death. Patients with vascular disease in more than one location of the body had the highest event rate at 40.5 percent at three years.
When projected over the global population who would mirror the patients in REACH, this represents millions of serious vascular events occurring every few years, many of which could be prevented.
“We were surprised by the high rate of these recurring vascular events,” said lead author Mark J. Alberts, M.D., professor of neurology at the Feinberg School and director of the stroke program at Northwestern Memorial Hospital. “We know how to prevent vascular disease and the events that it produces. This points to the need for better prevention, better use of medications and a need to develop more potent medications. These are the number one and two causes of death throughout the world.”
For full article, see link above.
Tags: heart attack cardiovascular blood vessel stroke reoccurance rehospitalization disease prevention risk
Whey Protein Improves Heart Health →
Aug 31, 2009 (Mercola.com)—A whey-protein-rich ingredient may improve blood vessel function in healthy individuals, reports a new randomized, double-blind study.
Two weeks of supplementation resulted in a 1.5 percent improvement in blood flow. According to the researchers, the whey protein-derived ingredient may work via an angiotensin converting enzyme (ACE)-inhibitory activity.
ACE inhibitors work by inhibiting the conversion of angiotensin I to the potent vasoconstrictor, angiotensin II, thereby improving blood flow and blood pressure.
Sources:
NutraIngredients August 5, 2009Nutrition Journal July 22, 2009; 8:34 [Free Full-Text Article]
Tags: whey protein heart cardiovascular blood vessel supplement angiotensin vascoconstrictor flow
Low-carb Diets Linked To Atherosclerosis And Impaired Blood Vessel Growth →
Aug 25, 2009 (Sciencedaily.com)—Even as low-carbohydrate/high-protein diets have proven successful at helping individuals rapidly lose weight, little is known about the diets’ long-term effects on vascular health.
Now, a study led by a scientific team at Beth Israel Deaconess Medical Center (BIDMC) provides some of the first data on this subject, demonstrating that mice placed on a 12-week low carbohydrate/high-protein diet showed a significant increase in atherosclerosis, a buildup of plaque in the heart’s arteries and a leading cause of heart attack and stroke. The findings also showed that the diet led to an impaired ability to form new blood vessels in tissues deprived of blood flow, as might occur during a heart attack.
Described in the online version of the Proceedings of the National Academy of Sciences (PNAS), the study also found that standard markers of cardiovascular risk, including cholesterol, were not changed in the animals fed the low-carb diet, despite the clear evidence of increased vascular disease.
“It’s very difficult to know in clinical studies how diets affect vascular health,” says senior author Anthony Rosenzweig, MD, Director of Cardiovascular Research in BIDMC’s CardioVascular Institute and Professor of Medicine at Harvard Medical School. “We, therefore, tend to rely on easily measured serum markers [such as cholesterol], which have been surprisingly reassuring in individuals on low-carbohydrate/high-protein diets, who do typically lose weight. But our research suggests that, at least in animals, these diets could be having adverse cardiovascular effects that are not reflected in simple serum markers.”
For full article, see link above.
Tags: cardiovascualr diet long term weight loss carbohydrate high protein atherosclerosis blood vessel cholesterol disease
Why Low Vitamin D Raises Heart Disease Risks In Diabetics →
Aug 25, 2009 (sciencedaily.com)—Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes, and researchers at Washington University School of Medicine in St. Louis now think they know why.
They have found that diabetics deficient in vitamin D can’t process cholesterol normally, so it builds up in their blood vessels, increasing the risk of heart attack and stroke. The new research has identified a mechanism linking low vitamin D levels to heart disease risk and may lead to ways to fix the problem, simply by increasing levels of vitamin D.
“Vitamin D inhibits the uptake of cholesterol by cells called macrophages,” says principal investigator Carlos Bernal-Mizrachi, M.D., a Washington University endocrinologist at Barnes-Jewish Hospital. “When people are deficient in vitamin D, the macrophage cells eat more cholesterol, and they can’t get rid of it. The macrophages get clogged with cholesterol and become what scientists call foam cells, which are one of the earliest markers of atherosclerosis.”
Macrophages are dispatched by the immune system in response to inflammation and often are activated by diseases such as diabetes. Bernal-Mizrachi and his colleagues believe that in diabetic patients with inadequate vitamin D, macrophages become loaded with cholesterol and eventually stiffen blood vessels and block blood flow.
For full article, see link above.
Tags: vitamin d diet nutrition diabetes deficient blood vessel heart attack stroke danger rosk cholesterol atherosclerosis immunity disease
Whey protein may improve heart health: Study →
Aug 5, 2009 (Sciencedaily.com)—A whey-protein-rich ingredient may improve blood vessel function in healthy individuals, reports a new randomised, double-blind study supported by Glanbia.
Two weeks of supplementation with a proprietary peptide (NOP847, Glanbia Nutritionals) resulted in a 1.5 per cent improvement in blood flow, report researchers from the University of Connecticut in the open access Nutrition Journal.
According to the researchers, the whey protein-derived ingredient, isolated from hydrolysate, may work via an angiotensin converting enzyme (ACE)-inhibitory activity.
ACE inhibitors work by inhibiting the conversion of angiotensin I to the potent vasoconstrictor, angiotensin II, thereby improving blood flow and blood pressure.
“The results of this preliminary study suggest that in individuals with normal endothelial function, the acute ingestion of a peptide derived from whey improves both conduit and resistance vascular responses,” wrote the authors, led by Kevin Ballard.
If further studies support the vascular benefits of the ingredient, it could see it enter the already buoyant heart health market. According to a recent market research conducted by Frost & Sullivan, the market is dominated by four ingredients: phytosterols; omega-3s; beta-glucans and soy protein.
For full article see link above.
Tags: whey protein heart supplement blood vessel function flow ace inhibitor blood pressure prevention endothelial cardiovascular
Freshly Crushed Garlic Better For The Heart Than Processed →
July 29, 2009 (Sciencedaily.com)—A new study reports what scientists term the first scientific evidence that freshly crushed garlic has more potent heart-healthy effects than dried garlic. Scheduled for the Aug. 12 issue of the Journal of Agricultural and Food Chemistry, it also challenges the widespread belief that most of garlic’s benefits are due to its rich array of antioxidants.
Instead, garlic’s heart-healthy effects seem to result mainly from hydrogen sulfide, a chemical signaling substance that forms after garlic is cut or crushed and relaxes blood vessels when eaten.
In the study, Dipak K. Das and colleagues point out that raw, crushed garlic generates hydrogen sulfide through a chemical reaction. Although best known as the stuff that gives rotten eggs their distinctive odor, hydrogen sulfide also acts as a chemical messenger in the body, relaxing blood vessels and allowing more blood to pass through. Processed and cooked garlic, however, loses its ability to generate hydrogen sulfide.
For full article see link above.
Tags: garlic fresh processed cooked blood vessel cardiovascular hydrogen sulfide antioxidant
Previous Exercise Helps Stroke Patients Recover Faster, Researchers Find →
July 17, 2009 (Sciencedaily.com)A person who has exercised regularly prior to the onset of a stroke appears to recover more quickly, say researchers from Mayo Clinic in Florida, who led a national study.
In the July 2009 issue of the Journal of Neurology, Neurosurgery & Psychiatry, the researchers reported that stroke patients who had previously exercised regularly before a stroke occurred were significantly more likely to have milder impairments and, thus, were better able to care for themselves, compared to patients who rarely exercised.
“It appears that exercise is very beneficial to people at risk of developing a stroke,” says Mayo Clinic neurologist James Meschia, M.D., the study’s lead investigator. “Many studies have shown that exercise can reduce the risk of developing a stroke in the first place, and this study suggests that if an active person does have a stroke, outcomes can be improved.”
For full article see link above.
Tags: exercise stroke prevention rehabilitation heart blood vessel impairment active fitness
Heart Transplant Recipients Can Improve Fitness And Perform High Intensity Workouts →
July 13, 2009 (Sciencedaily.com)—Heart transplant recipients’ cardio-respiratory fitness is around 30 to 50 per cent lower than age-matched healthy sedentary individuals. As a result, exercise rehabilitation should be very important to these patients, and a University of Alberta study shows they can improve their overall physical fitness.
Mark Haykowsky, in the Faculty of Rehabilitation Medicine, led the largest randomized exercise intervention trial in heart-transplant patients, which was published in the April edition of American Journal of Transplantation. The study involved 43 participants, half sedentary, and the other half on a 12-week exercise program. He found that exercise improved cardio-respiratory fitness, muscle mass and maximal strength; surprisingly, however, exercise training didn’t improve heart or blood-vessel function. Those exercising improved the size of the muscle mass, but blood vessels were still hardened and the heart’s ability to fill and relax was not improved.
For full article see link above.
Tags: cardio cardiovascular circulatory rehabilitation exercse heart transplant fitness muscle strength surgery blood vessel function
Income, Education, Important Factors In Heart Disease Risk →
June 18, 2009 (Sciencedaily.com) —Doctors who ignore the socioeconomic status of patients when evaluating their risk for heart disease are missing a crucial element that might result in inadequate treatment, according to a University of Rochester Medical Center study published in the June 2009 American Heart Journal.
The current model that most doctors use to assess risk, known as Framingham Risk Scoring (FRS), does not accurately predict whether a person of low income and/or less than a high school education will develop heart disease or die in the next 10 years, the study found. The FRS tool is limited to measuring data such as overall cholesterol and bad cholesterol levels, blood pressure, age and smoking status.
When socioeconomic factors were added into the FRS risk assessment, however, the proportion of low-income and low-education patients at risk for death or disease during the next 10 years was nearly double that of people with higher socioeconomic status. Thus, from a clinical perspective, asking about socioeconomic status when evaluating risk factors potentially increases the number of patients eligible for cholesterol-lowering medications, aspirin therapy, and supervised changes in diet and exercise, by about 15 percent, the study said.
“To our knowledge, this is the first study to examine the effect of adding socioeconomic status to the typical risk assessment in the United States,” said lead author Kevin Fiscella, M.D., M.P.H., professor of Family Medicine and Community and Preventive Medicine at URMC, and a national expert on disparities in health care.
For full article see link above.
Tags: heart disease treatment income education risk cholesterol blood vessel smoking age socioeconomic assessment
Individuals Who Apply Pesticides Are Found To Have Double The Risk Of Blood Disorder →
June 17, 2009 (Sciencedaily.com) —A study involving 678 individuals who apply pesticides, culled from a U.S. Agricultural Health Study of over 50,000 farmers, recently found that exposure to certain pesticides doubles one’s risk of developing an abnormal blood condition called MGUS (monoclonal gammopathy of undetermined significance) compared with individuals in the general population. The disorder, characterized by an abnormal level of a plasma protein, requires lifelong monitoring as it is a pre-cancerous condition that can lead to multiple myeloma, a painful cancer of the plasma cells in the bone marrow.
“Previously, inconclusive evidence has linked agricultural work to an increased multiple myeloma risk. Our study is the first to show an association between pesticide exposure and an excess prevalence of MGUS,” said lead author Ola Landgren, MD, PhD, of the National Cancer Institute (NCI), which is part of the National Institutes of Health, U.S. Department of Health and Human Services.
“This finding is particularly important given that we recently found in a large prospective cancer screening study that virtually all multiple myeloma patients experienced a MGUS state prior to developing myeloma.” “As several million Americans use pesticides, it’s important that the risks of developing MGUS from the use of pesticides is known,” added senior study author and NCI investigator Michael Alavanja, DrPH.
For full article see link above.
Tags: blood vessel pesticides cancer plasma bone marrow myeloma MGUS prevention risk farming circulatory
Common Spices Work Better than Aspirin to Stop Blood Clots →
June 16, 2009 (NaturalNews.com)— Spices do a whole lot more than liven up food. New research has found that the active ingredients in several common spices prevent platelet aggregation and blood clot formation up to 29 times better than aspirin, and without the side effects. Scientists in India have done extensive testing to determine the health benefits of spices traditionally used in Indian cuisine. In the latest research to come from the Central Food Technological Research Institute, they evaluated the effect of the principle spice active compounds eugenol, capsaicin, piperine, quercetin, curcumin, cinnamaldehyde, and allyl sulphide on human platelet aggregation. They demonstrated that each compound evaluated was able to significantly inhibit blood clotting. Furthermore, the compounds performed their anti-platelet aggregation activity against several different factors that promote the clotting of blood.
For full article see link above.
Tags: blood spice clot circulatory heart vessel eugenol capsaicin piperine quercetin curcumin cinnamaldehyde allyl sulphide cardiovascular
Use of Artificial Sweeteners Linked to Increase in Diabetes →
June 15, 2009 (Sciencedaily.com) —People who use artificial sweeteners are heavier, more likely to have diabetes, and more likely to be insulin-resistant compared with nonusers, according to data presented here during ENDO 2009, the 91st annual meeting of The Endocrine Society. Results show an inverse association between obesity and diabetes, on one side, and daily total caloric, carbohydrate, and fat intake, on the other side, when comparing artificial sweetener users and control subjects.
For full article see link above.
Tags: diabetes type 2 sweetner circulatory heart blood vessel overweight obesity endocrine fat glucose incretin
Cornflakes linked to heart disease →
June 13, 2009 (Presstv.com) —Adopting a diet rich in carbohydrates interferes with the function of blood vessels, placing the individual at an increased risk of cardiovascular disease.
Previous studies had considered high blood sugar levels after meals as a risk factor for cardiovascular disease, not only in patients with diabetes but also in the general population.
High-glycemic meals, such as white bread, cornflakes and instant potatoes, are reported to increase blood sugar levels more than foods with low-glycemic index — oatmeal, most fruits and vegetables, legumes and nuts.
According to a study published in the Journal of the American College of Cardiology, a diet rich in high-glycemic food is linked to higher risk of heart disease.
High-glycemic foods not only increase postprandial blood sugar levels but also interfere with the function of blood vessels, a key variable in the development of hardening of the arteries and heart disease increasing the cardiac events.
“The main take-home message is that high-glycemic index carbs are dangerous since they reduce or inhibit endothelial function, which is the ‘risk of the risk factors,’ leading to atherosclerosis and potentially leading to heart disease,” said Michael Shechter, the leader of the research team.
For full article see link above.
