Dr. John's Health Matters
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The articles posted here are from various sources who are duly acknowledged. I would appreciate being immediately notified, if any copywritten material needs to be removed. This blog is not intended to replace the qualified advice of a licensed health practitioner. Readers should exercise their own judgment. Enjoy, subscribe, participate and tell others :)
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Posts tagged "omega"
Tuesday, Sep 1st, 2009 ↓How Much Omega-3 Fatty Acid Do We Need To Prevent Cardiovascular Disease? →
Sept 1, 2009 (Sciencedaily.com)—A team of French scientists have found the dose of DHA (docosahexaenoic acid) that is “just right” for preventing cardiovascular disease in healthy men. In a research report appearing in the September 2009 print issue of The FASEB Journal, the scientists show that a 200 mg dose of DHA per day is enough to affect biochemical markers that reliably predict cardiovascular problems, such as those related to aging, atherosclerosis, and diabetes. This study is the first to identify how much DHA is necessary to promote optimal heart health.
“This study shows that regularly consuming small amounts of DHA is likely to improve the health status of people, especially in regards to cardiovascular function,” said Michel Lagarde, co-author of the study.
To determine the optimal dose of DHA, Lagarde and colleagues examined the effects of increasing doses of DHA on 12 healthy male volunteers between ages of 53 and 65. These men consumed doses of DHA at 200, 400, 800, and 1600 mg per day for two weeks for each dose amount, with DHA being the only omega-3 fatty acid in their diet. Blood and urine samples were collected before and after each dose and at eight weeks after DHA supplementation stopped. The researchers then examined these samples for biochemical markers indicating the effects of each dose on the volunteers.
“Now that we have a very good idea about how much DHA is just right, the next step is to try it out in an expanded clinical trial that involves many more people,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. “Until then, I’ll stick with tasty foods that contain DHA, like fish, rather than getting a quick fatty-acid fix at the local vitamin store.”
Journal reference:
- Nicolas Guillot, Emilie Caillet, Martine Laville, Catherine Calzada, Michel Lagarde, and Evelyne Véricel. Increasing intakes of the long-chain -3 docosahexaenoic acid: effects on platelet functions and redox status in healthy men. The FASEB Journal, 2009; 23 (9): 2909 DOI: 10.1096/fj.09-133421
Tags: omega fatty acid DHA heart cardiovascular supplement disease prevention atherosclerosis diabetes
Omega-3, vitamin E mix shows potential for autistic speech →
Aug 19, 2009 (Nutraingredients.com)—A combination of omega-3 fatty acids and vitamin E may lead to speech improvements in autistic children with verbal disorders, suggests a new study.
Verbal apraxia is a speech disorder common in autism, and an estimated 50 per cent of children with autism have apraxia. Furthermore, many thousands more are reported to have apraxia but are not autistic.
According to new research published in the journal Alternative Therapies in Health and Medicine, daily supplements of omega-3 and vitamin E were associated with improvements in speech, imitation, eye contact, and behaviour.
Claudia Morris from the Children’s Hospital and Research Center Oakland (CHRCO) and Marilyn Agin from the Saint Vincent Medical Center in New York recruited families with experiences of omega-3 fatty acid and vitamin E supplementation. The majority of families used doses of 800 IU of vitamin E, while the average omega-3 consumption was 280 to 840 mg DHA and 695 to 2,085mg EPA.
The ratios and dosages determined through the work with the study led to a patent for Dr Morris through the CHRCO (US patent # 2008/002216). The patented formulation is licensed exclusively to Illinois-based NourishLife from CHRCO.
Kate Bolton, VP of speech nutrients at NourishLife, told NutraIngredients: “The results of the study are significant in that 97 per cent of the participants with apraxia and/or on the autism spectrum reported dramatic improvements while taking a combination of omega-3 fatty acids and vitamin E.
“The study represents the largest summary of children with apraxia to date,” she added.
“Antidotal evidence had previously shown that omega-3 can help children with apraxia and those known as ‘late talkers’. The researchers discovered that they symptoms presented by children with apraxia mirror those of vitamin E deficiency,” said Bolton. “The addition of high dose vitamin E with omega-3 fatty acids is the breakthrough.”
For full article see link above.
Tags: vitamin e omega 3 fatty acid speech improvement autistic children child kid verbal disorder apraxia imitation eye contact behaviour supplement
Mounting Evidence Of Fish Oil's Heart Health Benefits →
Aug 5, 2009 (Sciencedaily.com)—There is mounting evidence that omega-3 fatty acids from fish or fish oil supplements not only help prevent cardiovascular diseases in healthy individuals, but also reduce the incidence of cardiac events and mortality in patients with existing heart disease. A new study, published in the August 11, 2009, issue of the Journal of the American College of Cardiology, extensively reviews data from a broad range of studies in tens of thousands of patients and sets forth suggested daily targets for omega-3 consumption.
“This isn’t just hype; we now have tremendous and compelling evidence from very large studies, some dating back 20 and 30 years, that demonstrate the protective benefits of omega-3 fish oil in multiple aspects of preventive cardiology,” said Carl Lavie, M.D., F.A.C.C., medical director of Cardiac Rehabilitation and Prevention, Ochsner Medical Center, New Orleans, LA, and lead author of the article. “The strongest evidence of a cardioprotective effect of omega-3s appears in patients with established cardiovascular disease and following a heart attack with up to a 30 percent reduction in CV-related death.”
Dietary intake of fish oil can also decrease the risk of atherosclerosis, arrhythmias, heart attack, sudden cardiac death and even health failure. Dr. Lavie adds that although there is a smaller benefit in reducing heart failure death—9 percent mortality benefit in a major recent randomized controlled trial—this is still very impressive given patients’ grave prognosis.
For full article see link above.
Tags: fish oil supplement omega fatty acid 3 cardiovascular diet atherosclerosis arrhythmia heart attack failure dha epa prevention
Omega-3, -6 levels linked to bowel health →
July 24, 2009 (Nutraingredients.com)—Increased intakes of omega-6 fatty acid linoleic acid may double the risk of ulcerative colitis, a type of inflammatory bowel disease, says a Pan-European study.
On the other hand, the highest intakes of omega-3 were associated with 77 per cent reduction in the risk of the disease, according to findings of the European Prospective Investigation into Cancer and Nutrition (EPIC) with 203,193 men and women published in Gut.
The study adds to a small but growing body of evidence supporting the importance of balance between omega-3 omega-6 fatty acids.
Talking to NutraIngredients.com, study author Dr Andrew Hart from the University of East Anglia said that the findings may ultimately be more relevant to people already suffering from ulcerative colitis, rather than for the entire population.
“I think it is a balance between the omega-3 and omega-6,” said Dr Hart “We’ve shown a positive correlation for omega-6 with a plausible biological mechanism, and a negative correlation for omega-3 with a plausible biological mechanism for that.”
For full article see link above.
Large Epidemiologic Study Supports Brain Power Of Fish In Older People →
July 18, 2009 (Sciencedaily.com)—Experts estimate that over 24 million people worldwide suffer from dementia, and many of these people live in low- and middle-income countries. Recently, there has been growing interest in whether dietary factors, particularly oily fish and meat, might influence the onset and/or severity of dementia. Oily fish are rich in omega-3 long-chain polyunsaturated fatty acids, which some studies suggest are positively related to cognitive function in later life.
Conversely, there is a suggestion from some studies that increased meat consumption may be related to cognitive decline. To examine this, a group of international researchers studied older people in 7 middle- to low-income countries. You can read the results of their study in the August 2009 issue of the American Journal of Clinical Nutrition.
For full article see link above.
Tags: supplement fish nutrition diet dementia omega 3 polyunsaturated cognitive function
Fish oil during pregnancy may slash infant allergy →
July 9, 2009 (nutraingredients.com)—Supplements of omega-3-rich fish oils during pregnancy may reduce the risk of food allergy and eczema in children, according to a new study from Sweden.
The occurrence of eczema and food allergies was 16 and 13 per cent lower, respectively, in infants of mothers receiving the fish oil supplements during pregnancy and the early months of breast-feeding, compared to placebo, according to findings published in the journal Acta Paediatrica.
“This randomized placebo-controlled double-blind study shows that omega-3 supplementation during pregnancy and lactation may reduce the risk of developing allergic sensitization to egg, IgE-associated eczema and food allergy during the first year of life,” wrote the authors, led by Catrin Furuhjelm from Linkoping University.
For full article see link above.
Can Your Diet Prevent Depression? →
July 3, 2009 (Mercola.com)—Depression is an established risk factor for the development of coronary heart disease (CHD). Dietary factors resulting in lower levels of omega-3 fats not only increase CHD risk, but may also cause depression.
Investigators measured red blood cell levels of two omega-3 fats, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and assessed depressive symptoms in a cross-sectional study of nearly 1,000 adults with CHD.
As EPA and DHA levels rose, depressive symptoms dropped. The prevalence of depression ranged from 23 percent in participants with the lowest blood levels of omega-3 fats to 13 percent in participants with the highest omega-3 blood levels.
Sources:
Tags: depression diet nutrition heart circulatory blood omega 3 RBC DHA CHD EPA prevention
Omega Fatty Acid Balance Can Alter Immunity And Gene Expression →
ScienceDaily (June 2, 2009) — For the past century, changes in the Western diet have altered the consumption of omega-6 fatty acids (w6, found in meat and vegetable oils) compared with omega-3 fatty acids (w3, found in flax and fish oil). Many studies seem to indicate this shift has brought about an increased risk of inflammation (associated with autoimmunity and allergy), and now using a controlled diet study with human volunteers, researchers may have teased out a biological basis for these reported changes.
Anthropological evidence suggests that human ancestors maintained a 2:1 w6/w3 ratio for much of history, but in Western countries today the ratio has spiked to as high as 10:1. Since these omega fatty acids can be converted into inflammatory molecules, this dietary change is believed to also disrupt the proper balance of pro- and anti- inflammatory agents, resulting in increased systemic inflammation and a higher incidence of problems including asthma, allergies, diabetes, and arthritis. Floyd Chilton and colleagues wanted to examine whether theses fatty acids might have other effects, and developed a dietary intervention strategy in which 27 healthy humans were fed a controlled diet mimicking the w6/w3 ratios of early humans over 5 weeks. They then looked at the gene levels of immune signals and cytokines (protein immune messengers), that impact autoimmunity and allergy in blood cells and found that many key signaling genes that promote inflammation were markedly reduced compared to a normal diet, including a signaling gene for a protein called PI3K, a critical early step in autoimmune and allergic inflammation responses.
This study demonstrates, for the first time in humans, that large changes in gene expression are likely an important mechanism by which these omega fatty acids exert their potent clinical effects.
Journal reference:
- Weaver et al. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. Journal of Biological Chemistry, 2009; DOI: 10.1074/jbc.M109.004861
